neuro-comorbidity-networks

Neuro-Comorbidity Networks

This repository hosts the website and resources for my PhD project:
Exploring Molecular Mechanisms of Comorbidity: A Network-Based Analysis of ADHD and Autism.

The project uses network-based systems biology approaches to investigate genetic and molecular mechanisms underlying comorbidity between neurodevelopmental and psychiatric disorders.

🌐 Project website

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🔎 Project Overview

Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are highly comorbid, and may share overlapping molecular mechanisms.
This project:

• Curates gene lists linked to ASD (~1600) and ADHD (~350)
• Focuses on proteins expressed at the neuronal synapse
• Builds a molecular network from >50 published proteomic studies (SynaptomeDB)
• Uses BioNAR and SynaptomeDB to integrate and analyse protein–protein interaction models

Future extensions may include other conditions, for example epilepsy and schizophrenia.

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📑 Publications & Outputs

• Sept 2025 – Poster at EuroBioConductor 2025.

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📂 Repository Structure

• index.md → homepage for the GitHub Pages website (to be added)
• about.md → detailed project description (to be added; For a project description and poster, see the abstract and poster here)
• publications.md → outputs and presentations
• README.md → this file

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⚖️ License

• Code in this repository is released under the MIT License.
• Data and text content (e.g., figures, datasets, abstracts) will be released under CC-BY 4.0 unless otherwise stated.

This means you are free to use, modify, and share this work, provided proper attribution is given.

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👤 About Me

I’m Dewy Nijhof, a PhD student at the Biomedical AI CDT programme at the University of Edinburgh.
Supervised by Dr Oksana Sorokina and Prof Douglas Armstrong.

📧 Email · 🌐 University Profile · 🧑‍💻 GitHub

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